My tactic for this mission is to rush into the middle and kill all the advancing Margonites. When they're dead, check for any Blashphemies. If there are none pick a rift to close, try to kill all the margonites and the claw as quick as possible, but the main thing to remember is even if a blashphemy starts to cap the middle just leave him alone. It takes him a long time to cap the centre, so finish what you're doing, then go deal with him. Again, when you're clear of Blashphemies go for another rift anf close that before heading back to the middle...rinse and repeat one final time. The only occaision I've ever had anything sit "guarding" the middle is when I've gone as Ritualist. I set myself up with offensive spirits and killed the Blashphemy and his 3 little orby friends whyle another player went (with my 3 heroes) to cap the rifts. The Blashphemy is there to make you panic...don't let him.
One final point to note is that the beginning of that mission seems to make or brake it. If you get killed by the group that rushes the middle don't get disheartened, just restart and prepare yourself well.
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